Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.
Identifieur interne : 00DA64 ( Main/Exploration ); précédent : 00DA63; suivant : 00DA65Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.
Auteurs : J W Mak [Malaisie] ; K. Suresh ; P L Lam ; M F Choong ; H P StriebelSource :
- Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ) [ 0177-2392 ] ; 1990.
Descripteurs français
- KwdFr :
- Administration par voie orale, Animaux, Antihelminthiques (usage thérapeutique), Brugia (), Cercopithecidae, Filaricides (administration et posologie), Filaricides (pharmacologie), Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Filarioses (traitement médicamenteux), Thiazoles (administration et posologie), Thiazoles (pharmacologie), Thiazoles (usage thérapeutique).
- MESH :
- administration et posologie : Filaricides, Thiazoles.
- pharmacologie : Filaricides, Thiazoles.
- traitement médicamenteux : Filariose lymphatique, Filarioses.
- usage thérapeutique : Antihelminthiques, Filaricides, Thiazoles.
- Administration par voie orale, Animaux, Brugia, Cercopithecidae.
English descriptors
- KwdEn :
- Administration, Oral, Animals, Anthelmintics (therapeutic use), Brugia (drug effects), Cercopithecidae, Elephantiasis, Filarial (drug therapy), Filariasis (drug therapy), Filaricides (administration & dosage), Filaricides (pharmacology), Filaricides (therapeutic use), Thiazoles (administration & dosage), Thiazoles (pharmacology), Thiazoles (therapeutic use).
- MESH :
- chemical , administration & dosage : Filaricides, Thiazoles.
- chemical , pharmacology : Filaricides, Thiazoles.
- chemical , therapeutic use : Anthelmintics, Filaricides, Thiazoles.
- drug effects : Brugia.
- drug therapy : Elephantiasis, Filarial, Filariasis.
- Administration, Oral, Animals, Cercopithecidae.
Abstract
CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.
PubMed: 2339241
Affiliations:
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Suresh</name></author><author><name sortKey="Lam, P L" sort="Lam, P L" uniqKey="Lam P" first="P L" last="Lam">P L Lam</name></author><author><name sortKey="Choong, M F" sort="Choong, M F" uniqKey="Choong M" first="M F" last="Choong">M F Choong</name></author><author><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1990">1990</date><idno type="RBID">pubmed:2339241</idno><idno type="pmid">2339241</idno><idno type="wicri:Area/PubMed/Corpus">005D95</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">005D95</idno><idno type="wicri:Area/PubMed/Curation">005D95</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">005D95</idno><idno type="wicri:Area/PubMed/Checkpoint">005D95</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">005D95</idno><idno type="wicri:Area/Ncbi/Merge">005605</idno><idno type="wicri:Area/Ncbi/Curation">005605</idno><idno type="wicri:Area/Ncbi/Checkpoint">005605</idno><idno type="wicri:doubleKey">0177-2392:1990:Mak J:antifilarial:activity:of</idno><idno type="wicri:Area/Main/Merge">00E668</idno><idno type="wicri:Area/Main/Curation">00DA64</idno><idno type="wicri:Area/Main/Exploration">00DA64</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Antifilarial activity of CGP 20376 against subperiodic Brugia malayi in the leaf-monkey Presbytis cristata.</title><author><name sortKey="Mak, J W" sort="Mak, J W" uniqKey="Mak J" first="J W" last="Mak">J W Mak</name><affiliation wicri:level="1"><nlm:affiliation>Institute for Medical Research, Kuala Lumpur, Malaysia.</nlm:affiliation><country xml:lang="fr">Malaisie</country><wicri:regionArea>Institute for Medical Research, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Suresh, K" sort="Suresh, K" uniqKey="Suresh K" first="K" last="Suresh">K. Suresh</name></author><author><name sortKey="Lam, P L" sort="Lam, P L" uniqKey="Lam P" first="P L" last="Lam">P L Lam</name></author><author><name sortKey="Choong, M F" sort="Choong, M F" uniqKey="Choong M" first="M F" last="Choong">M F Choong</name></author><author><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name></author></analytic><series><title level="j">Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ)</title><idno type="ISSN">0177-2392</idno><imprint><date when="1990" type="published">1990</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Anthelmintics (therapeutic use)</term><term>Brugia (drug effects)</term><term>Cercopithecidae</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Filariasis (drug therapy)</term><term>Filaricides (administration & dosage)</term><term>Filaricides (pharmacology)</term><term>Filaricides (therapeutic use)</term><term>Thiazoles (administration & dosage)</term><term>Thiazoles (pharmacology)</term><term>Thiazoles (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Antihelminthiques (usage thérapeutique)</term><term>Brugia ()</term><term>Cercopithecidae</term><term>Filaricides (administration et posologie)</term><term>Filaricides (pharmacologie)</term><term>Filaricides (usage thérapeutique)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Filarioses (traitement médicamenteux)</term><term>Thiazoles (administration et posologie)</term><term>Thiazoles (pharmacologie)</term><term>Thiazoles (usage thérapeutique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Filaricides</term><term>Thiazoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Filaricides</term><term>Thiazoles</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anthelmintics</term><term>Filaricides</term><term>Thiazoles</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Filaricides</term><term>Thiazoles</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Brugia</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term><term>Filariasis</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Filaricides</term><term>Thiazoles</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term><term>Filarioses</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antihelminthiques</term><term>Filaricides</term><term>Thiazoles</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Cercopithecidae</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Brugia</term><term>Cercopithecidae</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">CGP 20376, a 5-methoxyl-6-dithiocarbamic-S- (2-carboxy-ethyl) ester derivative of benzothiazole was evaluated for its antifilarial properties and shown to be extremely effective against subperiodic Brugia malayi in the leaf-monkey, Presbytis cristata at oral doses of 20-100 mg/kg. The compound and/or its metabolites had complete micro- and microfilaricidal activities even when given at a single dose of 20 mg/kg. Lower doses had incomplete filaricidal action.</div></front></TEI><affiliations><list><country><li>Malaisie</li></country></list><tree><noCountry><name sortKey="Choong, M F" sort="Choong, M F" uniqKey="Choong M" first="M F" last="Choong">M F Choong</name><name sortKey="Lam, P L" sort="Lam, P L" uniqKey="Lam P" first="P L" last="Lam">P L Lam</name><name sortKey="Striebel, H P" sort="Striebel, H P" uniqKey="Striebel H" first="H P" last="Striebel">H P Striebel</name><name sortKey="Suresh, K" sort="Suresh, K" uniqKey="Suresh K" first="K" last="Suresh">K. Suresh</name></noCountry><country name="Malaisie"><noRegion><name sortKey="Mak, J W" sort="Mak, J W" uniqKey="Mak J" first="J W" last="Mak">J W Mak</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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